Your browser doesn't support javascript.
loading
A multiphase very-low calorie ketogenic diet improves serum redox balance by reducing oxidative status in obese patients.
Bellanti, Francesco; Losavio, Francesca; Quiete, Stefano; Lo Buglio, Aurelio; Calvanese, Chiara; Dobrakowski, Michal; Kasperczyk, Aleksandra; Kasperczyk, Slawomir; Vendemiale, Gianluigi; Cincione, Raffaele Ivan.
Afiliação
  • Bellanti F; Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address: francesco.bellanti@unifg.it.
  • Losavio F; Department of Clinical and Experimental Medicine, University of Foggia, Italy.
  • Quiete S; Department of Medical and Surgical Sciences, University of Foggia, Italy.
  • Lo Buglio A; Department of Medical and Surgical Sciences, University of Foggia, Italy.
  • Calvanese C; Department of Medical and Surgical Sciences, University of Foggia, Italy.
  • Dobrakowski M; Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
  • Kasperczyk A; Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
  • Kasperczyk S; Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
  • Vendemiale G; Department of Medical and Surgical Sciences, University of Foggia, Italy.
  • Cincione RI; Department of Clinical and Experimental Medicine, University of Foggia, Italy.
Free Radic Biol Med ; 223: 109-117, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39094708
ABSTRACT
The very-low calorie ketogenic diet (VLCKD) is recommended as an effective dietary approach for the management of obesity. This study investigated changes in circulating biomarkers of redox homeostasis induced by a multiphase VLCKD in obese individuals. A total of 40 obese subjects were prescribed a multiphasic VLCKD for eleven weeks. Anthropometric measurements, body composition parameters, calorimetric measures, and standard laboratory markers of glucose and lipid metabolism were evaluated at baseline (T0) and at the end of the dietary intervention (T1). Additionally, circulating markers of oxidative damage and antioxidant status were analyzed in serum and erythrocytes. Compared to T0, at T1 the multiphase VLCKD induced significant weight loss and reduction of waist circumference, with beneficial effects on body composition parameters and the glucose/lipid biochemical profile. Moreover, a decrease in serum markers of oxidative damage was reported at T1, while no changes in serum markers of antioxidant status and in erythrocyte redox markers were observed. In addition, a significant association was found between variations in anthropometric measurements, body composition, glucose metabolism parameters, and changes in circulating markers of oxidative damage. Regression models showed that variation in lipofuscin was significant predictor of changes in body mass index, fat mass, visceral adiposity, and insulin sensitivity. In conclusion, this study demonstrated that the multiphase VLCKD improves serum redox balance by reducing markers of oxidative damage in obese individuals, highlighting the interplay between adiposity, glucose metabolism, and redox homeostasis in the pathogenesis of obesity. Furthermore, these data provide a rationale for future investigations aimed at testing serum lipofuscin as a reliable redox marker in obesity.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Estresse Oxidativo / Dieta Cetogênica / Obesidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Estresse Oxidativo / Dieta Cetogênica / Obesidade Idioma: En Ano de publicação: 2024 Tipo de documento: Article