Your browser doesn't support javascript.
loading
A descriptive analysis of drug-drug interactions and corresponding adverse drug reactions in multimorbid older inpatients: findings from the SENATOR trial.
Simal, Ine; Somers, Annemie; Amrouch, Cheima; Capiau, Andreas; Cherubini, Antonio; Cruz-Jentoft, Alfonso J; Gudmundsson, Adalsteinn; Soiza, Roy L; O 'Mahony, Denis; Petrovic, Mirko.
Afiliação
  • Simal I; Department of Pharmacy, Ghent University Hospital, Ghent, Belgium. ine.simal@uzgent.be.
  • Somers A; Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium. ine.simal@uzgent.be.
  • Amrouch C; Department of Pharmacy, Ghent University Hospital, Ghent, Belgium.
  • Capiau A; Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Cherubini A; Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
  • Cruz-Jentoft AJ; Department of Pharmacy, Ghent University Hospital, Ghent, Belgium.
  • Gudmundsson A; Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Soiza RL; Geriatria, Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento, IRCCS INRCA, 60127, Ancona, Italy.
  • O 'Mahony D; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Petrovic M; Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Eur Geriatr Med ; 2024 Aug 02.
Article em En | MEDLINE | ID: mdl-39095682
ABSTRACT

PURPOSE:

Drug-drug interactions (DDIs) are prevalent among multimorbid and polymedicated older adults and can increase the risk of adverse drug reactions (ADRs), hospital admissions, and mortality. This study describes the incidence and prevalence of 66 clinically relevant DDIs and analyses the occurrence of 12 corresponding predefined ADRs in older inpatients enrolled in the SENATOR trial.

METHODS:

The sub-study of the SENATOR trial that involved 1537 multimorbid older inpatients, recruited from 2016 to 2018 in six academic teaching hospitals in Belgium, Iceland, Ireland, Italy, Scotland, and Spain respectively, and analysed 66 potentially clinically significant DDIs. Descriptive analysis determined DDI and corresponding ADR prevalence/incidence.

RESULTS:

At baseline (median age 78 [72, 84], 52.8% male), the prevalence of patients with DDIs was high (50.9%), increased during hospitalisation (55.2%) and reduced to 49.7% after 12 weeks. The most common DDIs were ≥ 2 potassium reducing drugs (17.1%), ≥ 3 centrally acting drugs (9.0%), and SSRI + loop/thiazide diuretic (7.2%). Of all participants, one-third experienced a prevalent (36.6%)/incident (35.8%) ADR. Major serum electrolyte disturbance had the highest incidence (10.7%)/prevalence (11.5%). Incident ADRs were more common in patients with DDIs (p = 0.013). A higher prevalence of new onset falls (p = 0.013), major constipation (p = 0.004), and major serum electrolyte disturbances (p = 0.006) was observed in patients with related and thus potentially causal DDIs.

CONCLUSIONS:

Clinicians should, be aware of DDIs and the involved drug classes that can lead to an increased rate of ADRs in older multimorbid inpatients. Regularly reevaluating the appropriateness of the frequently prescribed drug classes and initiating judicious deprescribing is recommended.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article