Ene-Reductase-Catalyzed Aromatization of Simple Cyclohexanones to Phenols.
Angew Chem Int Ed Engl
; : e202408359, 2024 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-39106109
ABSTRACT
Direct aromatization of cyclohexanones to synthesize substituted phenols represents a significant challenge in modern synthetic chemistry. Herein, we describe a novel ene-reductase (TsER) catalytic system that converts substituted cyclohexanones into the corresponding phenols. This process involves the successive dehydrogenation of two saturated carbon-carbon bonds within the six-membered ring of cyclohexanones and utilizes molecular oxygen to drive the reaction cycle. It demonstrates a versatile and efficient approach for the synthesis of substituted phenols, providing a valuable complement to existing chemical methodologies.
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MEDLINE
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En
Ano de publicação:
2024
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Article