Chiral bifunctional sulfide-catalyzed enantioselective bromolactonizations of α- and ß-substituted 5-hexenoic acids.
Beilstein J Org Chem
; 20: 1794-1799, 2024.
Article
em En
| MEDLINE
| ID: mdl-39109297
ABSTRACT
Enantioselective halolactonizations of sterically less hindered alkenoic acid substrates without substituents on the carbon-carbon double bond have remained a formidable challenge. To address this limitation, we report herein the asymmetric bromolactonization of 5-hexenoic acid derivatives catalyzed by a BINOL-derived chiral bifunctional sulfide.
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MEDLINE
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En
Ano de publicação:
2024
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Article