Enteroendocrine cells regulate intestinal homeostasis and epithelial function.
Mol Cell Endocrinol
; 593: 112339, 2024 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-39111616
ABSTRACT
Enteroendocrine cells (EECs) are well-known for their systemic hormonal effects, especially in the regulation of appetite and glycemia. Much less is known about how the products made by EECs regulate their local environment within the intestine. Here, we focus on paracrine interactions between EECs and other intestinal cells as they regulate three essential aspects of intestinal homeostasis and physiology 1) intestinal stem cell function and proliferation; 2) nutrient absorption; and 3) mucosal barrier function. We also discuss the ability of EECs to express multiple hormones, describe in vitro and in vivo models to study EECs, and consider how EECs are altered in GI disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Células Enteroendócrinas
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Homeostase
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Mucosa Intestinal
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article