6-Gingerol modulates miRNAs and PODXL gene expression via methyltransferase enzymes in NB4 cells: an in silico and in vitro study.

Afgar, Ali; Ramezani Zadeh Kermani, Mahdiyeh; Pabarja, Athareh; Afgar, Amir Reza; Kavyani, Batoul; Arezoomand, Hossein; Zanganeh, Saeed; Sanaei, Mohammad Javad; Sattarzadeh Bardsiri, Mahla; Vahidi, Reza

Afgar, Ali; Ramezani Zadeh Kermani, Mahdiyeh; Pabarja, Athareh; Afgar, Amir Reza; Kavyani, Batoul; Arezoomand, Hossein; Zanganeh, Saeed; Sanaei, Mohammad Javad; Sattarzadeh Bardsiri, Mahla; Vahidi, Reza.

Afiliação

Afgar A; Research Center for Hydatid Diseases in Iran, Kerman University of Medical Sciences, Kerman, Iran.
Ramezani Zadeh Kermani M; Department of Mathematics, Shahid Bahonar University of Kerman, Kerman, Iran.
Pabarja A; Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Afgar AR; Research Center for Hydatid Diseases in Iran, Kerman University of Medical Sciences, Kerman, Iran.
Kavyani B; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Arezoomand H; Department of Hematology and Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Zanganeh S; Stem Cells and Regenerative Medicine Innovation Center, Kerman University of Medical Sciences, Kerman, Iran.
Sanaei MJ; School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sattarzadeh Bardsiri M; Stem Cells and Regenerative Medicine Innovation Center, Kerman University of Medical Sciences, Kerman, Iran. sabasatarzadeh3261@gmail.com.
Vahidi R; Student Research Committee, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran. sabasatarzadeh3261@gmail.com.

Sci Rep ; 14(1): 18356, 2024 08 07.

Article em En | MEDLINE | ID: mdl-39112503

Assuntos

Catecóis; Álcoois Graxos; MicroRNAs; Catecóis/farmacologia; Catecóis/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Humanos; Álcoois Graxos/farmacologia; Linhagem Celular Tumoral; DNA (Citosina-5-)-Metiltransferase 1/metabolismo; DNA (Citosina-5-)-Metiltransferase 1/genética; DNA Metiltransferase 3A; DNA (Citosina-5-)-Metiltransferases/metabolismo; DNA (Citosina-5-)-Metiltransferases/genética; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/metabolismo; Simulação por Computador; Biologia Computacional/métodos

Palavras-chave

PODXL gene; AML; Docking; Methyltransferase; MiRNA; Molecular dynamic simulation; NB4 cell line

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catecóis / MicroRNAs / Álcoois Graxos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catecóis / MicroRNAs / Álcoois Graxos Idioma: En Ano de publicação: 2024 Tipo de documento: Article