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A chitosan-based light-curing hydrogel dressing for accelerated healing of infected wounds.
Wu, Hang; Zhu, Liang; Xie, Lei; Zhou, Taiyu; Yu, Tengbo; Zhang, Yingze.
Afiliação
  • Wu H; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, PR China. Electronic address: wuhang@qdu.edu.cn.
  • Zhu L; Department of Orthopaedic Surgery, Qingdao Municipal Hospital, Qingdao University, No.1 Jiaozhou Road, Qingdao 266000, PR China.
  • Xie L; Department of Orthopaedic Surgery, Qingdao Municipal Hospital, Qingdao University, No.1 Jiaozhou Road, Qingdao 266000, PR China.
  • Zhou T; School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, PR China.
  • Yu T; Department of Orthopaedic Surgery, Qingdao Municipal Hospital, Qingdao University, No.1 Jiaozhou Road, Qingdao 266000, PR China. Electronic address: tengbo.yu@qdu.edu.cn.
  • Zhang Y; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, PR China; Trauma Emergency Center of the Third Affiliated Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang 050051, PR China. Electronic address: dryzzhang@126
Int J Biol Macromol ; 278(Pt 3): 134609, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39134197
ABSTRACT
Bacterial infections, excessive reactive oxygen species (ROS) accumulation and a persistent inflammatory response severely impede the wound healing process. In this study, we developed a novel multifunctional hydrogel dressing (LCPN) based on lipoic acid modified chitosan (LAMC), polypyrrole nanoparticles (PPy NPs) and nicotinamide mononucleotide (NMN) for accelerated healing of infected wounds. The synthesized LCPN hydrogel has several properties. Modification of lipoic acid significantly enhances the water solubility of chitosan making it easier to dissolve and absorb wound secretions. Interestingly, owing to the breaking and restructuring of disulfide bonds, LCPN hydrogel can be quickly bonded under UV light without relying on photoinitiators. In addition, the incorporation of PPy NPs not only enhances the electrical conductivity of LCPN hydrogel, but also confers photothermal antimicrobial capability to LCPN hydrogel. More importantly, the sustained release of NMN in LCPN hydrogel can significantly enhance cell proliferation, migration and antioxidant capacity, which is conducive to accelerated wound healing. In vitro and in vivo experiments have shown that LCPN hydrogel has excellent biocompatibility and the ability to promote wound healing. Therefore, the prepared multifunctional hydrogel is expected to be used as a novel dressing to accelerate wound healing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Hidrogéis / Quitosana Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Hidrogéis / Quitosana Idioma: En Ano de publicação: 2024 Tipo de documento: Article