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PharmVar GeneFocus: CYP4F2.
Zubiaur, Pablo; Rodríguez-Antona, Cristina; Boone, Erin C; Daly, Ann K; Tsermpini, Evangelia Eirini; Khasawneh, Lubna Q; Sangkuhl, Katrin; Duconge, Jorge; Botton, Mariana R; Savieo, Jessica; Nofziger, Charity; Whirl-Carrillo, Michelle; Klein, Teri E; Gaedigk, Andrea.
Afiliação
  • Zubiaur P; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM) and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IP), Madrid, Spain.
  • Rodríguez-Antona C; Pharmacogenomics and Tumor Biomarkers Group, Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) CSIC/UAM, Madrid, Spain.
  • Boone EC; Centro de Investigación Biomédica en Red de Enfermedades Raras, Valencia, Spain.
  • Daly AK; Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Research Institute (CMRI), Kansas City, Missouri, USA.
  • Tsermpini EE; Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Khasawneh LQ; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Sangkuhl K; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE.
  • Duconge J; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
  • Botton MR; Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, USA.
  • Savieo J; Transplant Immunology and Personalized Medicine Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Nofziger C; Postgraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Whirl-Carrillo M; Department of Clinical Operations, AccessDx, Houston, Texas, USA.
  • Klein TE; PharmGenetix GmbH, Niederalm, Austria.
  • Gaedigk A; Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
Clin Pharmacol Ther ; 2024 Aug 13.
Article em En | MEDLINE | ID: mdl-39135485
ABSTRACT
The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This GeneFocus provides a comprehensive overview and summary of CYP4F2 genetic variation including the characterization of 14 novel star alleles, CYP4F2*4 through *17. A description of how haplotype information cataloged by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC) is also provided.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article