SURFACTANT PROTEIN A: AN INNATE IMMUNE MODULATOR AND THERAPEUTIC IN ASTHMA.
Trans Am Clin Climatol Assoc
; 134: 94-112, 2024.
Article
em En
| MEDLINE
| ID: mdl-39135597
ABSTRACT
Surfactant Protein A (SP-A) is an innate immune modulator produced by the lung with known protective effects against bacteria and viruses. Its role in asthma, an inflammatory lung disease that affects 10% of the world's population, is not entirely known. In this review, we demonstrate that SP-A confers protection against exposure to interleukin-13, a type 2 cytokine integral to eosinophilic asthma, in a mouse model of SP-A deficiency, a house dust mite model of asthma, and in human bronchial epithelial cells from participants with asthma. We also show that small peptides derived from SP-A, such as the major allele of single nucleotide polymorphism (SNP) rs1965708, which includes the carbohydrate recognition domain of SP-A2 at position 223, reduce airway hyperresponsiveness, airway eosinophils, and mucus in a mouse model of asthma. These data suggest that SP-A has beneficial effects relevant to asthma and that an SP-A peptide may have a new therapeutic use in asthma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
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Proteína A Associada a Surfactante Pulmonar
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Modelos Animais de Doenças
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Imunidade Inata
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article