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The Alzheimer's Disease Neuroimaging Initiative Clinical Core.
Aisen, Paul S; Donohue, Michael C; Raman, Rema; Rafii, Michael S; Petersen, Ronald C.
Afiliação
  • Aisen PS; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Donohue MC; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Raman R; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Rafii MS; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
  • Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement ; 2024 Aug 13.
Article em En | MEDLINE | ID: mdl-39136045
ABSTRACT
The Alzheimer's Disease Neuroimaging Initiative (ADNI) Clinical Core is responsible for coordination of all clinical activities at the ADNI sites, including project management, regulatory oversight, and site management and monitoring, as well as the collection of all clinical data and management of all study data. The Clinical Core is also charged with determining the clinical classifications and criteria for enrollment in evolving AD trials and enabling the ongoing characterization of the cross-sectional features and longitudinal trajectories of the ADNI cohorts with application of these findings to optimal clinical trial designs. More than 2400 individuals have been enrolled in the cohorts since the inception of ADNI, facilitating refinement of our understanding of the AD trajectory and allowing academic and industry investigators to model therapeutic trials across the disease spectrum from the presymptomatic stage through dementia. HIGHLIGHTS Since 2004, the Alzheimer's Disease Neuroimaging Initiative (ADNI) Clinical Core has overseen the enrollment of > 2400 participants with mild cognitive impairment, mild Alzheimer's disease (AD) dementia, and normal cognition. The longitudinal dataset has elucidated the full cognitive and clinical trajectory of AD from its presymptomatic stage through the onset of dementia. The ADNI data have supported the design of most major trials in the field.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article