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Association of healthy lifestyle factors and genetic liability with bipolar disorder: Findings from the UK Biobank.
Li, Guoxian; He, Qida; Sun, Mengtong; Ma, Ze; Zhao, Hanqing; Wang, Yu; Feng, Zhaolong; Li, Tongxing; Chu, Jiadong; Hu, Wei; Chen, Xuanli; Han, Qiang; Sun, Na; Liu, Xiaoqin; Sun, Hongpeng; Shen, Yueping.
Afiliação
  • Li G; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • He Q; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Sun M; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Ma Z; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Zhao H; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Wang Y; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Feng Z; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Li T; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Chu J; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Hu W; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Chen X; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Han Q; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Sun N; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China.
  • Liu X; The National Centre for Register-based Research, Aarhus University, Denmark.
  • Sun H; Department of Department of Child Health, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China. Electronic address: hpsun@suda.edu.cn.
  • Shen Y; Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, PR China. Electronic address: shenyueping@suda.edu.cn.
J Affect Disord ; 364: 279-285, 2024 Nov 01.
Article em En | MEDLINE | ID: mdl-39137837
ABSTRACT

BACKGROUND:

The interplay between genetic and lifestyle factors in the development of bipolar disorder (BD) remains unclear.

METHODS:

A cohort study was carried out on 365,517 participants from the UK Biobank. Lifestyle scores, based on smoking, physical activity, diet, alcohol consumption, sedentary behavior, sleep duration, and social contact, were grouped as favorable (scores 6-7), intermediate (scores 4-5), or unfavorable (scores 0-3). The BD polygenic risk score (PRS) was also categorized into high, intermediate, and low-risk groups using PRS tertiles. Cox regression models determined hazard ratios (HRs) and 95 % confidence intervals (CIs) for BD.

RESULTS:

During the 12.9-year follow-up, 529 individuals developed BD. Comparing those with favorable lifestyles to those with unfavorable participants, the HR of developing BD was 3.28 (95 % CI, 2.76-3.89). Similarly, individuals with a high PRS had a risk of 3.20 (95 % CI, 2.83-3.63) compared to those with a low PRS. Notably, individuals with both a high PRS and an unfavorable lifestyle had a significantly higher risk of BD (HR = 6.31, 95 % CI, 4.14-9.63) compared to those with a low PRS and a favorable lifestyle. Additionally, the interaction between PRS and lifestyle contributed an additional risk, with a relative excess risk of 1.74 (95 % CI, 0.40-3.07) and an attributable proportion due to the interaction of 0.37 (95 % CI, 0.16-0.58).

CONCLUSIONS:

Our findings suggest that genetic liability for BD, measured as PRS, and lifestyle have an additive effect on the risk of developing BD. A favorable lifestyle was associated with a reduced risk of developing BD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Consumo de Bebidas Alcoólicas / Fumar / Bancos de Espécimes Biológicos / Estilo de Vida Saudável Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Consumo de Bebidas Alcoólicas / Fumar / Bancos de Espécimes Biológicos / Estilo de Vida Saudável Idioma: En Ano de publicação: 2024 Tipo de documento: Article