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Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes.
Attaye, Ilias; Witjes, Julia J; Koopen, Annefleur M; van der Vossen, Eduard W J; Zwirs, Diona; Wortelboer, Koen; Collard, Didier; Kemper, Elles Marleen; Winkelmeijer, Maaike; Holst, Jens J; Hazen, Stanley L; Kuipers, Folkert; Stroes, Erik S G; Groen, Albert K; de Vos, Willem M; Nieuwdorp, Max; Herrema, Hilde.
Afiliação
  • Attaye I; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Witjes JJ; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands.
  • Koopen AM; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, Metabolism and Nutrition, Amsterdam, the Netherlands.
  • van der Vossen EWJ; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Zwirs D; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands.
  • Wortelboer K; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, Metabolism and Nutrition, Amsterdam, the Netherlands.
  • Collard D; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Kemper EM; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands.
  • Winkelmeijer M; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, Metabolism and Nutrition, Amsterdam, the Netherlands.
  • Holst JJ; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Hazen SL; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Kuipers F; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Stroes ESG; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands.
  • Groen AK; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, Metabolism and Nutrition, Amsterdam, the Netherlands.
  • de Vos WM; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Nieuwdorp M; Department of Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
  • Herrema H; Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
iScience ; 27(8): 110455, 2024 Aug 16.
Article em En | MEDLINE | ID: mdl-39139405
ABSTRACT
This randomized, double-blind, placebo-controlled trial investigated the impact of 14-day Anaerobutyricum soehngenii L2-7 supplementation on postprandial glucose levels in 25 White Dutch males with type 2 diabetes (T2D) on stable metformin therapy. The primary endpoint was the effect of A. soehngenii versus placebo on glucose excursions and variability as determined by continuous glucose monitoring. Secondary endpoints were changes in ambulatory 24-h blood pressure, incretins, circulating metabolites and excursions of plasma short-chain fatty acids (SCFAs) and bile acids upon a standardized meal. Results showed that A. soehngenii supplementation for 14 days significantly improved glycemic variability and mean arterial blood pressure, without notable changes in SCFAs, bile acids, incretin levels, or anthropometric parameters as compared to placebo-treated controls. Although well-tolerated and effective in improving glycemic control in the intervention group, further research in larger and more diverse populations is needed to generalize these findings.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article