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Development and validation of a novel questionnaire to describe and assess sensations and triggers associated with refractory and unexplained chronic cough.
Galgani, Shannon; Sawyer, Chelsea; King, Jenny; Dockry, Rachel; Wingfield-Digby, James; Holt, Kimberly; Mitchell, Joanne; Sen, Shilpi; Birchall, Danielle; Solari, Francesca; Smith, Jacky; Yorke, Janelle.
Afiliação
  • Galgani S; Cough Research Team, Manchester University NHS Foundation Trust, Manchester, UK.
  • Sawyer C; Division of Psychology and Mental Health, The University of Manchester, Manchester, UK.
  • King J; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.
  • Dockry R; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.
  • Wingfield-Digby J; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.
  • Holt K; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.
  • Mitchell J; Cough Research Team, Manchester University NHS Foundation Trust, Manchester, UK.
  • Sen S; Cough Research Team, Manchester University NHS Foundation Trust, Manchester, UK.
  • Birchall D; Simplifying Science, Warrington, UK.
  • Solari F; Trauma and Orthopaedics, Ysbyty Gwynedd, Bangor, UK.
  • Smith J; Division of Infection, Immunity and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.
  • Yorke J; School of Nursing, The Hong Kong Polytechnic University, Hong Kong, Hong Kong janelle.yorke@polyu.edu.hk.
BMJ Open Respir Res ; 11(1)2024 Aug 13.
Article em En | MEDLINE | ID: mdl-39142695
ABSTRACT

INTRODUCTION:

Refractory or unexplained chronic cough (RUCC) is a common clinical problem with no effective diagnostic tools. The Sensations and Triggers Provoking Cough questionnaire (TOPIC) was developed to characterise cough in RUCC versus cough in other conditions.

METHODS:

Content analysis of participant interviews discussing the sensations and triggers of chronic cough informed TOPIC development. Participants with chronic cough completed the draft-TOPIC (a subset repeating 5-7 days later), St George's Respiratory Questionnaire (SGRQ), Cough Severity Diary (CSD) and Global Rating of Change Scale. The draft-TOPIC item list was reduced in hierarchical and Rasch analysis to refine the questionnaire to the TOPIC.

RESULTS:

49 items describing the triggers and sensations of cough were generated from participant interviews (RUCC n=14, chronic obstructive pulmonary disease (COPD) n=11, interstitial lung disease (ILD) n=10, asthma n=11, bronchiectasis n=3, cystic fibrosis n=7). 140 participants (median age 60.0 (19.0-88.0), female 56.4%; RUCC n=39, ILD n=38, asthma n=45, COPD n=6, bronchiectasis n=12) completed draft-TOPIC, where items with poor 'fit' for RUCC were removed to create TOPIC (8 trigger items, 7 sensation items). Median TOPIC score was significantly higher in RUCC (37.0) vs ILD (24.5, p=0.009) and asthma (7.0, p<0.001), but not bronchiectasis (20.0, p=0.318) or COPD (18.5, p=0.238), likely due to small sample sizes. The Rasch model demonstrated excellent fit in RUCC (χ2=22.04, p=0.85; PSI=0.88); as expected. When all participant groups were included, fit was no longer demonstrated (χ2=66.43, p=0.0001, PSI=0.89) due to the increased heterogeneity (CI=0.077). TOPIC correlated positively with SGRQ (r=0.47, p<0.001) and CSD (r=0.63, p<0.001). The test-retest reliability of TOPIC (intraclass correlation coefficient) was excellent (r=0.90, p<0.001).

CONCLUSIONS:

High TOPIC scores in the RUCC patients suggest their cough is characterised by specific sensations and triggers. Validation of TOPIC in cough clinics may demonstrate value as an aid to identify features of RUCC versus cough in other conditions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tosse Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tosse Idioma: En Ano de publicação: 2024 Tipo de documento: Article