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Effective treatment of relapsed/refractory CD19-positive B/T-type mixed-phenotype acute leukemia with blinatumomab: A case report.
Aoki, Masanori; Ishikawa, Maho; Sato, Tsugumi; Taji, Yoshitada; Kayano, Hidekazu; Takahashi, Naoki; Ebihara, Yasuhiro.
Afiliação
  • Aoki M; Clinical Laboratory Saitama Medical University International Medical Center Hidaka Saitama Japan.
  • Ishikawa M; Department of Hemato-Oncology Saitama Medical University International Medical Center Hidaka Saitama Japan.
  • Sato T; Department of Diagnostic Pathology Saitama Medical University International Medical Center Hidaka Saitama Japan.
  • Taji Y; Clinical Laboratory Saitama Medical University International Medical Center Hidaka Saitama Japan.
  • Kayano H; Department of Diagnostic Pathology Saitama Medical University International Medical Center Hidaka Saitama Japan.
  • Takahashi N; School of Medical Technology, Faculty of Health & Medical Care Saitama Medical University Hidaka Saitama Japan.
  • Ebihara Y; Department of Hemato-Oncology Saitama Medical University International Medical Center Hidaka Saitama Japan.
EJHaem ; 5(4): 855-858, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39157609
ABSTRACT
A 26-year-old man was diagnosed with B/T-type mixed-phenotype acute leukemia (MPAL-B/T) based on blasts being positive for CD19, cytoplasmic CD3, and cyCD79a, but negative for myeloperoxidase. Acute lymphoblastic leukemia-based chemotherapy was started, but the leukemia was refractory. He underwent cord blood transplantation with the conditioning regimen of total body irradiation plus cyclophosphamide and cytarabine with granulocyte-colony stimulating factor priming. Prophylaxis for graft versus host disease was performed with short-term methotrexate and cyclosporin. The leukemia relapsed in bone marrow 20 months later. At that time, he was treated with inotuzumab ozogamicin because the blasts expressed CD22 (75.4%), but this was ineffective. He was next administered blinatumomab with dexamethasone pretreatment, resulting in a complete remission (CR). He subsequently underwent human leukocyte antigen-haploidentical peripheral blood stem cell transplantation. He has still maintained a CR for 12 months. Blinatumomab might be a promising treatment and a bridge to stem cell transplantation even in relapsed/refractory CD19-expressing MPAL-B/T.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article