Anti-photoaging activity of triterpenoids isolated from Centella asiatica.
Phytochemistry
; 228: 114246, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-39163914
ABSTRACT
Centella asiatica (L.) Urban is a medical plant rich in triterpenoids, frequently used in Asia to treat skin conditions such as acne. To search for anti-photoaging agents, 16 known triterpenoids and five undescribed triterpenoids, including three ursane, one oleanane and one nor-ursane were isolated from the whole herb of C. asiatica. The structures and relative stereochemistry of these compounds were elucidated by detailed NMR spectra and HRESIMS. Compounds 1 and 2 were isomers of ursane-type and oleane-type triterpenes with rare aldehyde groups on C-23. Compound 4 was a unique example of a nor-ursane type triterpenoid. The Ultraviolet B (UVB) induced HaCaT cell damage model was used to measure the in vitro anti-photoaging activity of all 21 compounds. Twenty compounds significantly increased HaCaT viability and inhibited lactate dehydrogenase (LDH) release after UVB exposure. These findings highlight the protective effects of C. asiatica-derived triterpenoids against UVB damage and indicate their potential as natural agents that can protect the skin against photoaging.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Raios Ultravioleta
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Centella
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article