Influence of membrane on the antigen presentation of the HIV-1 envelope membrane proximal external region (MPER).
Curr Opin Struct Biol
; 88: 102897, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39173417
ABSTRACT
The membrane proximal external region (MPER) of the HIV envelope glycoproteins has generated renewed interest after a recent phase I vaccine trial that presented MPER lipid-peptide epitopes demonstrated promise to elicit a broad neutralization response. The antigenicity of MPER is intimately associated with the membrane, and its presentation relies significantly on the lipid composition. This review brings together recent findings on the influence of membranes on the conformation of MPER and its recognition by broadly neutralizing antibodies. Specifically, the review highlights the importance of properly accounting for the balance between protein-protein and membrane-protein interactions in vaccine design.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
HIV-1
/
Apresentação de Antígeno
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article