Neohesperidin exerts antidepressant-like effect via the mechanistic target of rapamycin complex 1 in the medial prefrontal cortex in male mice.
J Pharmacol Sci
; 156(2): 82-85, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39179338
ABSTRACT
Neohesperidin, a citrus flavonoid, shows potential for activating the mechanistic target of rapamycin complex 1 (mTORC1). Here, the antidepressant-like effect of neohesperidin was examined in male ICR mice (naïve mice and mice treated repeatedly with prednisolone, a synthetic glucocorticoid, which induces depression-like behavior). Oral neohesperidin administration exerted an antidepressant-like effect in the forced swim test 1 h post-treatment, in naïve mice; this effect was no longer observed at 24 h. Neohesperidin also reversed prednisolone-induced depression-like behavior. This effect was blocked by infusing rapamycin, an mTORC1 inhibitor, into the medial prefrontal cortex. Neohesperidin may rapidly produce an antidepressant-like effect.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
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Depressão
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Alvo Mecanístico do Complexo 1 de Rapamicina
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Hesperidina
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Antidepressivos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article