The Formation and Renewal of Photoreceptor Outer Segments.
Cells
; 13(16)2024 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-39195247
ABSTRACT
The visual system is essential for humans to perceive the environment. In the retina, rod and cone photoreceptor neurons are the initial sites where vision forms. The apical region of both cone and rod photoreceptors contains a light-sensing organelle known as the outer segment (OS), which houses tens of thousands of light-sensitive opsins. The OSs of photoreceptors are not static; they require rhythmic renewal to maintain normal physiological functions. Disruptions in OS renewal can lead to various genetic disorders, such as retinitis pigmentosa (RP). Understanding the patterns and molecular mechanisms of photoreceptor OS renewal remains one of the most intriguing topics in visual biology. This review aims to elucidate the structure of photoreceptor OSs, the molecular mechanisms underlying photoreceptor OS renewal, and the retinal diseases resulting from defects in this renewal process. Additionally, we will explore retinal diseases related to photoreceptor OS renewal and potential therapeutic strategies, concluding with a discussion on future research directions for OS renewal.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Segmento Externo das Células Fotorreceptoras da Retina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article