Comparison of One-Year Outcome of Intravitreal Aflibercept with or without Photodynamic Therapy for Polypoidal Choroidal Vasculopathy.
Medicina (Kaunas)
; 60(8)2024 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-39202592
ABSTRACT
Background and Objectives:
Our study compared the visual and anatomical outcomes of polypoidal choroidal vasculopathy (PCV) patients receiving intravitreal aflibercept (IVA) with or without photodynamic therapy (PDT) over 12 months. Materials andMethods:
This retrospective study was performed for 60 eyes from 60 patients with treatment-naïve PCV. Thirty eyes were treated using IVA monotherapy (IVA group), and thirty eyes were treated using a combination of IVA with PDT (IVA/PDT group). The baseline characteristics, treatment outcomes, and retreatment rates were compared between the two groups over a one-year follow-up period.Results:
The best-corrected visual acuity (BCVA) was found to have improved significantly in the IVA/PDT group at every 3-month visit. However, no significant BCVA improvement was observed in the IVA group. A significantly lower retreatment rate and higher dry macula rate were found in the IVA/PDT group than that in the IVA group. In the entire population of the study, a better baseline vision and younger age were associated with better final visual outcomes. Retreatment was associated with poor baseline BCVA and IVA monotherapy.Conclusions:
The combination of IVA and PDT may offer superior visual improvement and a higher dry macula rate compared to IVA monotherapy in the treatment of PCV patients while requiring fewer retreatments over 12 months.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Proteínas Recombinantes de Fusão
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Acuidade Visual
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Receptores de Fatores de Crescimento do Endotélio Vascular
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Injeções Intravítreas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article