Sex difference in the association between creatinine-to-cystatin C ratio and metabolic syndrome among Chinese adults.
Front Endocrinol (Lausanne)
; 15: 1389295, 2024.
Article
em En
| MEDLINE
| ID: mdl-39205686
ABSTRACT
Background:
Metabolic syndrome (MetS), characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, affects 20-25% of the global population. The creatinine-to-cystatin C ratio (CCR) is an indicator of skeletal muscle mass. While CCR may play a role in MetS development, sex differences in these associations are not fully understood. Therefore, this study aimed to investigate how CCR levels are associated with MetS in a Chinese adult population, focusing on possible sex disparities.Method:
We conducted a retrospective cross-sectional analysis of 9,376 adults from Xiamen Chang Gung Hospital between 2014 to 2016. We examined the relationship between CCR and MetS, adjusting for cardiometabolic risk factors.Results:
The prevalence of MetS was 24.7% in males and 18.0% in females. Interestingly, we observed significant sex differences in the association between CCR quartiles and MetS. Females in the lowest CCR quartile had a significantly higher risk of MetS (odds ratio=1.84). Receiver operating characteristic curve analysis revealed acceptable diagnostic power of CCR for MetS in females (area under the curve=0.65) but not in males.Conclusion:
Our findings suggest that CCR is an independent risk factor for MetS in females, highlighting the importance of sex-specific assessments when evaluating MetS risk.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores Sexuais
/
Creatinina
/
Síndrome Metabólica
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Cistatina C
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article