Electron Attachment to the Nucleobase Uracil in Diethylene Glycol: The Signature of a Doorway.
Chemphyschem
; : e202400581, 2024 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-39221972
ABSTRACT
The cellular environment plays a significant role in low energy electron-mediated radiation damage to genetic materials. In this study, we have modeled the effect of the bulk medium on electron attachment to nucleobases in diethylene glycol (DEG) using uracil as a test case, in accordance with recent experimental work on the observation of dissociative quasi-free electron attachment to nucleoside via excited anion radical in solution (in DEG). Our EOM-CCSD-based quantum mechanical/molecular mechanical (QM/MM) simulations indicate that the electron scavenging by uracil in DEG is much slower than that observed in the aqueous medium due to its viscosity. This work also establishes that a doorway mechanism exists in uracil microsolvated and bulk solvated with DEG, with the dipole-bound state and solvent-bound state acting as doorway states, respectively.
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article