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Quantitative assessment of gadolinium deposition in dentate nuclei with MR fingerprinting.
Wang, Yang; Fushimi, Yasutaka; Nakajima, Satoshi; Sakata, Akihiko; Okuchi, Sachi; Otani, Sayo; Tagawa, Hiroshi; Ikeda, Satoshi; Ito, Shuichi; Tanji, Masahiro; Ibi, Yumiko; Morita, Satoshi; Urushibata, Yuta; Arakawa, Yoshiki; Nakamoto, Yuji.
Afiliação
  • Wang Y; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Fushimi Y; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN. Electronic address: yfushimi@kuhp.kyoto-u.ac.jp.
  • Nakajima S; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Sakata A; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Okuchi S; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Otani S; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Tagawa H; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Ikeda S; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Ito S; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Tanji M; Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Ibi Y; Department of Clinical Trial Science, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Morita S; Department of Clinical Trial Science, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Urushibata Y; Siemens Healthcare K. K., Tokyo 141-8644, JAPAN.
  • Arakawa Y; Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
  • Nakamoto Y; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507 JAPAN.
Acad Radiol ; 2024 Sep 02.
Article em En | MEDLINE | ID: mdl-39227216
ABSTRACT
RATIONALE AND

OBJECTIVES:

Gadolinium deposition in the dentate nucleus (DN) has been evaluated by T1-weighted imaging (T1WI) and T1 (R1) mapping, but not MR fingerprinting (MRF). This study investigated associations between T1 and T2 values of DN and gadolinium-based contrast agents (GBCAs) using 2-dimensional MRF. MATERIALS AND

METHODS:

This study included 101 patients. Region of interest analysis was performed for T1 and T2 values of DN on MRF (T1-MRF, T2-MRF) and T1-weighted images (T1WI ratio). T1 and T2 ratios compared to normal cerebellar white matter (T1-MRF ratio, T2-MRF ratio) were calculated. The type of previous GBCA was confirmed in 79 patients, and linear regressions were performed between T1, T2 values and number of GBCAs.

RESULTS:

Good correlations were observed between T1-MRF and T1WI ratio (ρ = -0.69, P < 0.001) and between T1-MRF ratio and T1WI ratio (ρ = -0.76, P < 0.001). Mild correlations were observed between T2-MRF and T1WI ratio (ρ = -0.32, P < 0.001) and between T2-MRF ratio and T1WI ratio (ρ = -0.44, P < 0.001). The number of linear-type GBCAs was associated with T1-MRF (ß = -0.62, P < 0.001) and T1-MRF ratio (ß = -0.54, P < 0.001) in univariate linear regression analyses, and with T1-MRF (ß = -0.61, P < 0.001) and T1-MRF ratio (ß = -0.53, P < 0.001) in multivariate analysis. The number of linear-type GBCAs was associated with T2-MRF (ß = -0.30, P < 0.001) and T2-MRF ratio (ß = -0.29, P < 0.001) in univariate analyses, and with T2-MRF (ß = -0.31, P < 0.001) and T2-MRF ratio (ß = -0.32, P < 0.001) in multivariate analyses. No associations were observed between number of macrocyclic GBCAs and T1-MRF (ratio) or T2-MRF (ratio).

CONCLUSION:

The number of linear-type GBCA administrations was associated with lower T1 and T2 values (ratios) in DN.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article