Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018.
Front Endocrinol (Lausanne)
; 15: 1439326, 2024.
Article
em En
| MEDLINE
| ID: mdl-39247923
ABSTRACT
Background:
The correlation between various insulin resistance surrogates and frailty remains under investigation in the scientific community.Methods:
Data from NHANES (1999-2018) were used. We utilized weighted binary logistic regression, trend tests, RCS analysis, and subgroup analysis to comprehensively assess the link between METS-IR, HOMA-IR, and TyG, and frailty risk.Results:
The results revealed a significant positive association between high levels of METS-IR, HOMA-IR, and TyG with the risk of frailty in all models. Notably, in model 4, the highest quintile of METS-IR showed the strongest link (OR 2.960, 95% CI 2.219-3.949), with HOMA-IR (OR 2.522, 95% CI 1.927-3.301) following closely behind. Trend tests revealed a positive trend between METS-IR, HOMA-IR, and TyG with the risk of frailty (P for trend < 0.05). RCS analysis showed a linear relationship between METS-IR and the risk of frailty (P for nonlinearity > 0.05). In contrast, HOMA-IR and TyG exhibited a U-shaped nonlinear relationship (P for nonlinearity < 0.05).Conclusion:
The research identified a linear association between METS-IR and frailty risk, whereas HOMA-IR and TyG displayed a U-shaped, nonlinear relationship pattern with the risk of frailty. Among the varying levels examined, the linkage between METS-IR and frailty was most pronounced in the top quintile.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Inquéritos Nutricionais
/
Fragilidade
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article