cPEPmatch Webserver: A comprehensive tool and database to aid rational design of cyclic peptides for drug discovery.
Comput Struct Biotechnol J
; 23: 3155-3162, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-39253058
ABSTRACT
Cyclic peptides have emerged as versatile scaffolds in drug discovery due to their stability and specificity. Here, we present the cPEPmatch webserver (accessible at https//t38webservices.nat.tum.de/cpepmatch/), an easy-to-use interface for the rational design of cyclic peptides targeting protein-protein interactions combined with a semi-quantitative evaluation of binding stability. This platform also offers access to a comprehensive database of cyclic peptide crystal structures. We demonstrate the webserver's utility through a series of case studies involving medically relevant protein systems, highlighting its potential to significantly advance drug discovery efforts.
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MEDLINE
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En
Ano de publicação:
2024
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Article