Application of self-assembled antibacterial nanofiber loaded oriented artificial skin in infected diabetic-related wound regeneration.
J Biomater Appl
; : 8853282241267253, 2024 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-39297741
ABSTRACT
Diabetic patients develop wounds that exhibit delayed healing, prolonged inflammatory responses, and slower epithelialization kinetics compared to non-diabetic patients. Diabetic foot ulcers(DFUs) affect approximately 18.6 million people worldwide. The presence of a high glucose microenvironment in DFUs results in the significant accumulation of bacterial infection and advanced glycation end products (AGEs). To solve this, a self-assemble antibacterial nanofiber(ANF) loaded oriential artificial skin (ANF@OAS) was introduced in this research, which is consisted of L/D-phenylalanine derivatives coupled the natural antimicrobial peptides. The ANF@OAS can effectively reduce AGEs production and suppress multiple resistant bacteria. Additionally, the ANF@OAS can suppress infection and stimulate wound healing in infected diabetic mice.
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MEDLINE
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En
Ano de publicação:
2024
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Article