Cortical Laminar Necrosis as a Rare Complication of Streptococcus pneumoniae Meningitis: A Case Report.

ABSTRACT

Cortical laminar necrosis (CLN) is a rare neurological complication that refers to ischemic injury of selective neuronal cortical layers. This condition often gets triggered by hypoxia, hypoglycemia, status epilepticus, immunosuppressive therapy, and rarely infection. This case report highlights the clinical presentation, diagnostic challenges, management, and outcomes of a patient who developed CLN due to bacterial meningitis. A 54-year-old woman with no significant medical history presented with high-grade fever, vomiting, and headache for two days. The clinical findings and cerebrospinal fluid (CSF) analysis indicated bacterial meningitis, leading to the initiation of empirical intravenous antibiotics. Despite initial improvement with antibiotics, the patient's condition worsened on day four, and she presented with increased headache and dizziness. An MRI performed on day four revealed CLN. Streptococcus pneumoniae was subsequently identified as the causative agent, and the antibiotic regimen was escalated based on the CSF culture and sensitivity results. By day nine, the patient experienced pain relief and a fever reduction. Although there were initial cognitive deficits, these improved significantly by the end of the second week with conservative management. The patient was discharged at the end of the second week, with a follow-up brain MRI scheduled one month later. This case highlights the critical importance of early recognition and aggressive management of bacterial meningitis to prevent neurological complications such as CLN. MRI plays a key role in neuroprotection for patients with CLN. Long-term follow-up and optimal antibiotic therapy are essential for safeguarding patient outcomes and ensuring quality of life.