Damage Control Orthopaedics induced less trauma-induced coagulopathy than Early Total Care in a porcine polytrauma model.

ABSTRACT

INTRODUCTION: Coagulopathic disorders (CD) complicate treatment in polytraumatised patients. Against this background, operative strategies for fracture management are controversial in this cohort. This study therefore investigated the effects of two established operative concepts, Early Total Care (ETC) and Damage Control Orthopaedics (DCO), on CD in a large animal polytrauma (PT) model. METHODS: Animals (sus scrofa) sustained PT involving blunt chest trauma, liver laceration, bilateral femur fracture, and pressure-controlled haemorrhagic shock. After resuscitation, animals were allocated to ETC (n=8), DCO (n=8), or served as a non-traumatised control group (CG, n=6). Animals were ventilated and monitored under ICU standards for 72 h. Blood samples were collected at baseline and post-trauma after 1.5, 2.5, 24, 48, and 72 h. Plasminogen Activator Inhibitor-1 (PAI-1) and thrombin-antithrombin complex (TAT) concentrations were determined by ELISA. RESULTS: Compared to the CG, ETC and DCO subjects had significantly increased plasma concentrations of PAI-1 after 2.5 h (CG vs. ETC p= 0.0050, CG vs. DCO p= 0.0016). Furthermore, the ETC group showed significantly increased plasma PAI-1 concentrations after 24 h compared to the CG and DCO group (CG vs. ETC p= 0.0002, DCO vs. ETC p= 0.0004). During the later clinical course, concentrations of TAT were significantly increased in the ETC group compared to the CG and DCO group after 72 h (CG vs. ETC p= 0.0290, DCO vs. ETC p= 0.0322). CONCLUSION: PT is strongly associated with CD in the early posttraumatic course. In comparison to DCO, ETC appeared to be negatively associated with CD. Future studies must investigate this impact, especially in those patients admitted with trauma-induced coagulopathy, to improve outcomes.