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Reward neurocircuitry predicts longitudinal changes in alcohol use following trauma exposure.
Hinojosa, Cecilia A; van Rooij, Sanne J H; Fani, Negar; Ellis, Robyn A; Harnett, Nathaniel G; Lebois, Lauren A M; Ely, Timothy D; Jovanovic, Tanja; Murty, Vishnu P; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Bruce, Steven E; Pizzagalli, Diego A; Sheridan, John F; Harte, Steven E; Koenen, Karestan C; Kessler, Ronald C; McLean, Samuel A; Ressler, Kerry J; Stevens, Jennifer S.
Afiliação
  • Hinojosa CA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: cecilia.a.hinojosa@emory.edu.
  • van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Ellis RA; McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  • Harnett NG; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Ely TD; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
  • Murty VP; Department of Psychology, Temple University, Philadelphia, PA, USA.
  • House SL; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Beaudoin FL; Department of Health Services, Policy, and Practice, The Alpert Medical School of Brown University, Providence, RI, USA; Department of Emergency Medicine, The Alpert Medical School of Brown University, Providence, RI.
  • An X; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Neylan TC; Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Clifford GD; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Linnstaedt SD; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Germine LT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; The Many Brains Project, Belmont, MA, USA.
  • Rauch SL; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, McLean Hospital, Belmont, MA, USA.
  • Haran JP; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Storrow AB; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lewandowski C; Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA.
  • Musey PI; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Hendry PL; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.
  • Sheikh S; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.
  • Jones CW; Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA.
  • Punches BE; Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, USA; Ohio State University College of Nursing, Columbus, OH, USA.
  • Hudak LA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • Pascual JL; Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Seamon MJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA.
  • Harris E; Department of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, USA.
  • Pearson C; Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, USA.
  • Peak DA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Merchant RC; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Domeier RM; Department of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, USA.
  • Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
  • O'Neil BJ; Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, USA.
  • Sergot P; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, USA.
  • Bruce SE; Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA.
  • Pizzagalli DA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Sheridan JF; Division of Biosciences, Ohio State University College of Dentistry, Columbus, OH, USA; Institute for Behavioral Medicine Research, OSU Wexner Medical Center, Columbus, OH, USA.
  • Harte SE; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Koenen KC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
  • McLean SA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Institute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Ressler KJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Biol Psychiatry Cogn Neurosci Neuroimaging ; 2024 Oct 08.
Article em En | MEDLINE | ID: mdl-39389310
ABSTRACT

BACKGROUND:

Trauma is a risk factor for developing maladaptive alcohol use. Preclinical research has shown that stress alters the processing of midbrain and striatal reward and incentive signals. However, little research has been conducted on alterations in reward-related neurocircuitry post-trauma in humans. Neuroimaging markers may be particularly useful as they can provide insight into the mechanisms that may make an individual vulnerable to developing trauma-related psychopathologies. This study aimed to identify reward-related neural correlates associated with changes in alcohol use after trauma exposure.

METHODS:

Participants were recruited from U.S. emergency departments for the AURORA study (N=286, 178 female). Trauma-related change in alcohol use at 8 weeks post-trauma relative to pre-trauma was quantified as a change in 30-day total drinking per the PhenX Toolkit Alcohol 30-Day Quantity and Frequency Measure. Reward-related neurocircuitry activation and functional connectivity (FC) were assessed 2 weeks post-trauma using fMRI during a monetary reward task using region of interest and whole-brain voxelwise analyses.

RESULTS:

Greater increase in alcohol use from pre-trauma to 8 weeks post-trauma was predicted by (1) greater ventral tegmental area (VTA) and (2) greater cerebellum activation during Gain>Loss trials measured 2 weeks post-trauma and (3) greater seed-based FC between the VTA and lateral occipital cortex and precuneus.

CONCLUSIONS:

Altered VTA activation and FC early post-trauma may be associated with reward-seeking and processing, contributing to greater alcohol use post-trauma. These data provide novel evidence of neural correlates that underlie increased alcohol use early post-trauma that may be targeted via early interventions to prevent the development of maladaptive alcohol use.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article