Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma.
Cancer Genet Cytogenet
; 15(1-2): 99-107, 1985 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-3967222
ABSTRACT
A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Teratoma
/
Cromossomos Humanos 6-12 e X
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article