Radioisotopic and synthetic studies related to caroxazone metabolism in man.
Arzneimittelforschung
; 29(9): 1412-6, 1979.
Article
em En
| MEDLINE
| ID: mdl-583252
ABSTRACT
Labelled 2-oxo-2H-1,3-benzoxazine-3(4H)-acetamide (caroxazone), has been synthesized by condensing N-(2-hydroxylbenzyl/glycinamide with 14C phosgene. Metabolic studies were performed administering the labelled drug to man and recovering metabolites from the urines. Beside the unchanged drug, five metabolites were identified and confirmed by synthesis, namely (3,4-dihydro-3-carboxamidomethyl-2-oxo-2H-1,3-benzoxazin-4-yl)urea (IX), N-carboxamidomethyl o-hydroxymethylphenyl carbamate (V), 4-methoxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide (VIIIa), 2-oxo-2H-1,3-benzoxazine-3(4H)acetic acid (III) and 4-hydroxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide (IV).
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Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Antidepressivos
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article