Effects of prolactin, bromocriptine and sulpiride on estrogen and lactogenic receptors in the rat adrenal gland.

ABSTRACT

In prepubertal male rats, the injection of bromocriptine (Br) for 10 days caused an increase in adrenal weight (Br 0.75 mg/kg BW (Br I) 2.83%; Br 1.5 mg/kg BW (Br II) 12.1% and Br 3 mg/kg BW (Br III) 24.7%), and this effect was only significant at the highest dose. Sulpiride (S, 30 mg/kg BW/day) for 10 days produced a significant decrease in adrenal weight (18.6%), whereas ovine prolactin (oPRL) administered at doses of 0.5 or 5 mg/kg BW/day for 10 had no effect on this parameter. The action of these drugs on corticosterone serum levels was for Br III a 50.6% increase and for S a 29.2% decrease. Bromocriptine caused a significant increment of cytosolic available estrogen receptors C 7.65 +/- 0.36 (SE); Br I 10.2 +/- 0.36; Br II 11.0 +/- 0.23 and Br III 13.3 +/- 0.35) and total lactogenic receptors in the adrenal gland (C 125.2 +/- 2.84; Br I 203.8 +/- 4.43; Br II 213.1 +/- 7.58 and Br III 251.3 +/- 10.4), and this effect was dose-related. oPRL diminished adrenal estrogen receptors only at the highest dose used (C 11.1 +/- 1.73; PRL 5 8.2 +/- 0.75) as did S (C 11.2 +/- 1.84 and S 5.2 +/- 1.07); while the former originated a marked decrease in lactogenic adrenal binding sites at both doses (C 198.7 +/- 12.2; PRL 0.5 52.9 +/- 5.00 and PRL 5 38.8 +/- 4.76), S also had a highly significant diminution over these receptors.(ABSTRACT TRUNCATED AT 250 WORDS)