Tissue-specific control of alpha 2u globulin gene expression: constitutive synthesis in the submaxillary gland.
Cell
; 32(2): 453-60, 1983 Feb.
Article
em En
| MEDLINE
| ID: mdl-6186396
ABSTRACT
Synthesis of alpha 2u globulin, previously thought to occur only in the male rat liver, has now been demonstrated in the submaxillary salivary gland. Unlike liver, submaxillary synthesis of alpha 2u globulin mRNA is constitutive--that is, independent of the endocrine state, age and sex. Liver and submaxillary alpha 2u globulin mRNAs are of similar size, and their 5' ends map to the same region of the gene. Isoelectric focusing of in vitro translation products revealed that submaxillary mRNA encodes a more acidic subset of alpha 2u globulins than does liver. Salivary alpha 2u globulin mRNA manifests 5% nucleotide divergence, encoding 20 amino acid substitutions, which specifies a more acidic polypeptide than its hepatic counterpart. Thus the liver and submaxillary gland synthesize alpha 2u globulin from different sets of genes that are subject to very different developmental and hormonal control.
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Base de dados:
MEDLINE
Assunto principal:
Glândula Submandibular
/
Alfa-Globulinas
/
RNA Mensageiro
/
Regulação da Expressão Gênica
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article