Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome.
Nature
; 302(5906): 346-9, 1983.
Article
em En
| MEDLINE
| ID: mdl-6188056
ABSTRACT
The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation. For example, this evolutionary relationship is reflected during meiosis in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Sexuais
/
Cromossomo X
/
Cromossomo Y
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article