The influence of 3-aminopropansulphonic acid (3-APS) on thalamic neurons.

ABSTRACT

The possible pathways conducting pain are still being discussed. One of the possible pathways may pass through the centrum medianum (CM). In the present study the activity of neurones of CM in cats was recorded using glass-micropipettes. 3-aminopropansulphonic acid (3-APS), which is a GABA analogue was administered intravenously in a dose of 0.1, 0.2, 0.5 and 1.0 mmol/kg. The depressive effect starts at the dose of 0.2 mmol/kg. The duration of the effect depends on the dose of 3-APS. Hence 3-APS has a very strong effect on other thalamic neurones so that it may be used for influencing their activity.