[Adrenergic control of pancreatic glucagon secretion]. / Controllo adrenergico della secrezione del glucagone pancreatico.
Boll Soc Ital Biol Sper
; 57(10): 1068-74, 1981 May 30.
Article
em It
| MEDLINE
| ID: mdl-6271149
ABSTRACT
In order to characterize the adrenergic control of pancreatic A cell, the effect on the glucagon secretion of three sympathomimetic substances (epinephrine, isoproterenol, phenylephrine) and two adrenergic blockers (propranolol and phentolamine) have been separately examined by the isolated perfused rat pancreas. The study was performed in basal state and during glucagon hypersecretion induced by arginine or glucopenia. Epinephrine and isoproterenol infusion determined a prompt an sustained glucagon release both in the basal state and during glucagon hypersecretion. The effect of phenylephrine infusion was slight. In the presence of propranolol, glucagon secretion induced by metabolic stimulus was significantly depressed. The glucagon secretion in the same experimental conditions was insignificantly enhanced by phentolamine. Finally propranolol infusion reverse the glucagon secretion induced by phenylephrine. In conclusion the pancreatic glucagon secretion in our model of study is clearly induced by B adrenergic receptor stimulation.
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Base de dados:
MEDLINE
Assunto principal:
Glucagon
/
Ilhotas Pancreáticas
/
Receptores Adrenérgicos
/
Receptores Adrenérgicos beta
Idioma:
It
Ano de publicação:
1981
Tipo de documento:
Article