Characterization of the hemopoietic target cells for the avian leukemia virus E26.
Virology
; 129(1): 65-78, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6310886
ABSTRACT
The dual leukemogenic response, involving both the erythroid and myeloid hemopoietic systems in chickens infected with E26 virus, has previously been described (C. Moscovici, J. Samarut, L. Gazzolo, and M. G. Moscovici, 1981. Virology 113, 765-768; K. Radke, H. Beug, S. Kornfeld, and T. Graf, 1982. Cell 31, 643-653). Similarly, the in vitro response of the two lineages resulted in the concomitant transformation and proliferation of erythroblast and myeloblast leukemic cells. The present study, using embryonic tissues at very early stages of development, was valuable in implying that E26 target cells are recruited among uncommitted erythroid-myeloid stem cells as well as myeloid- or erythroid-committed progenitor cells. Therefore, E26 may be the first avian retrovirus capable of interacting with uncommitted hemopoietic precursor cells.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Transformação Celular Viral
/
Vírus da Leucose Aviária
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article