[Modification of DNA damage in rat hepatocytes following whole-body roentgen radiation using cysteamine and 8-bromocaffeine]. / Modifitsiruemost' povrezhdenii v DNK gepatotsitov krys posle obshchego rentgenovskogo oblucheniia s pomoshch'iu tsisteamina i 8-bromkofeina.

ABSTRACT

Using the elastoviscosimetric method it was shown that the level of residual DNA double-strand breaks in rat hepatocytes depended on conditions of total-body X-irradiation it increased in the presence of a sensitizer, 8-bromocaffeine and decreased in the presence of a protector, cysteamine. This correlation confirms a major role of fixed DNA double-strand breaks in the formation of a lethal effect in a cell.