[Cysteamine in the treatment of cystinosis in children. In vitro and in vivo studies]. / La cystéamine dans le traitement de la cystinose infantile. Etudes in vitro et in vivo.
Pediatrie
; 39(8): 619-33, 1984 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-6535971
ABSTRACT
The effect of cysteamine was studied in 6 children with nephropathic cystinosis. In 3 of them an in vitro study on fibroblasts was performed. The cystine content of fibroblasts was immediately diminished (about 90% of total cystine content) as soon as the concentration of cysteamine in the medium was greater than or equal to 0,1 mmole/l. In vivo, 50 to 89 mg/kg/day of cysteamine was administered for 9 to 37 months (mean 21,3). There was no adverse reaction. In all cases a dramatic decline in leukocyte cystine level was observed (in 5 cases the level was within the range seen in clinically unaffected heterozygotes). Growth was not improved. The renal function was stabilised in 3 cases. Photophobia which was present in 4 children decreased in 2 cases or disappeared in 2 cases.
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Base de dados:
MEDLINE
Assunto principal:
Cisteamina
/
Cistinose
Idioma:
Fr
Ano de publicação:
1984
Tipo de documento:
Article