Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.
J Exp Med
; 158(4): 1350-5, 1983 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-6578293
ABSTRACT
(NZB x NZW)F1 mice spontaneously develop an autoimmune syndrome characterized by a fatal immune complex glomerulonephritis. Administration of monoclonal antibodies specific for an I region gene product (I-Az) of the H-2 haplotype associated with susceptibility to glomerulonephritis in these animals produced a remission in female mice with established renal disease. The results demonstrated that anti-I-A therapy stabilized the level of proteinuria and increased the 1-yr survival rate from 10% to greater than 90% in treated animals relative to control mice. These findings may ultimately have therapeutic potential for the treatment of systemic lupus erythematosus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe II
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Modelos Animais de Doenças
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Lúpus Eritematoso Sistêmico
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Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article