Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole.
Int J Nucl Med Biol
; 10(4): 205-10, 1983.
Article
em En
| MEDLINE
| ID: mdl-6662623
ABSTRACT
[82Br]Misonidazole ( [82Br]MISO) was investigated as a potential agent for scintillation imaging and indexing of hypoxic areas in tumor masses. [82Br]MISO was prepared by irradiating samples of Br-MISO in a SLOWPOKE reactor for 2 h at a thermal neutron flux of 10(12) n cm-2 s-1. Radiochemical yields ranged from 11 to 16%. [82Br]MISO had a plasma clearance half-life of approximately 40 min in BALB/c mice bearing EMT-6 tumors. The major metabolic product was identified as [82Br]Desmisonidazole. [82Br]MISO showed relatively high tumor uptake and persistently high plasma levels.
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Base de dados:
MEDLINE
Assunto principal:
Radiossensibilizantes
/
Radioisótopos
/
Bromo
/
Neoplasias Mamárias Experimentais
/
Misonidazol
/
Nitroimidazóis
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article