Termination of very early pregnancy by RU 486--an antiprogestational compound.
Contraception
; 29(5): 399-410, 1984 May.
Article
em En
| MEDLINE
| ID: mdl-6744860
ABSTRACT
PIP: RU 486, a new antiprogestational compound, was given to 37 women seeking termination of pregnancy and with amenorrhea of 42 days or less. 1 patient was found at the 2nd follow-up visit to have an extrauterine pregnancy. The patients received either 25 mg, 50 mg, or 100 mg RU 486 twice daily for 4 days. All patients attended 3 follow-up visits, 1, 2, and 5-6 weeks after the start of therapy. The start, duration, and amount of bleeding as well as plasma progesterone, beta-human chorionic gonadotropin (hCG) and cortisol concentrations were determined for each treatment day and at follow-up visits. All but 3 patients started to bleed during treatment. Frequency of complete abortion was 61% (22 of 36 patients). In only 3 patients was the pregnancy unaffected by treatment. The clinical efficacy of the treatment was not dose-dependent. Most of the patients experienced only minor dise effects in terms of mild uterine pain, nausea, and vomiting. However, 2 patients suffered from heavy bleeding requiring blood transfusion and curettage. In patients with complete abortion, beta-hCG values decreased significantly but not until the 1ft follow-up visit. The plasma progesterone also decreased. This decrease appeared earlier with the higher daily dose of RU 486. Cortisol concentrations increased during treatment with all 3 dosage regimens but the levels remained within the normal range. It is concluded the treatment with RU 486 may provide a novel therapy for menstrual regulation but the efficacy of it needs to be improved to compete with such alternatives as vacuum aspiration.
Palavras-chave
Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Bleeding; Corpus Luteum Hormones; Diseases; Equipment And Supplies; Evaluation; Examinations And Diagnoses; Family Planning; Fertility Control, Postconception; Gonadotropins; Gonadotropins, Chorionic; Hormones; Physical Examinations And Diagnoses; Pregnancy; Pregnancy, First Trimester; Progesterone; Reproduction; Reproductive Control Agents; Signs And Symptoms; Steroid Abortifacients--administraction and dosage; Ultrasonics
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Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Abortivos
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Abortivos Esteroides
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Aborto Induzido
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Estrenos
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article