Systemic, bladder wall, and bladder tumor concentration of misonidazole following intravesical administration in the rat.
Int J Radiat Oncol Biol Phys
; 9(9): 1397-400, 1983 Sep.
Article
em En
| MEDLINE
| ID: mdl-6885552
ABSTRACT
The hypoxic-cell radiosensitizer misonidazole was administered intravesically to normal and to bladder tumor-bearing female Fischer rats. Drug concentration was measured in the bladder wall, the tumor and in the serum using high pressure liquid chromatography at different times following administration. The data shows that misonidazole is readily adsorbed by the bladder wall and the tumor with tissue levels reaching up to 10 times those measured in the serum.
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Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Misonidazol
/
Nitroimidazóis
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article