Synthesis of perhydro-1,4-thiazepines, of expected pharmacological activity. Part III. 4-(2-hydroxyethyl)-perhydro-1,4-thiazepine esters.
Pol J Pharmacol Pharm
; 35(1): 63-8, 1983.
Article
em En
| MEDLINE
| ID: mdl-6889187
ABSTRACT
New esters, derivatives or the title aminoalcohol, were obtained by three classical methods in the reaction of 4-(2-hydroxyethyl)-perhydro-1,4-thiazepine (HEPT) with chlorides (method a), acid potassium salts (method b), and sodium HEPT salts with acid chlorides (method c). Compounds 3 and 5 have weak spasmolytic properties; 5 in a dose of approx. 50 mg/kg strongly depressed the central nervous system.
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Base de dados:
MEDLINE
Assunto principal:
Parassimpatolíticos
/
Tiazepinas
/
Depressores do Sistema Nervoso Central
/
Cloretos
/
Compostos de Bário
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article