Acute erythroleukaemia with L3 morphology and the 14q+ chromosome.
Scand J Haematol
; 29(1): 75-82, 1982 Jul.
Article
em En
| MEDLINE
| ID: mdl-6956958
ABSTRACT
L3 morphology according to the FAB classification and the 14q+ chromosome are usually ascribed to the Burkitt type of leukaemia or lymphoma with a B or pre-B cell phenotype. We report here a case of adult acute leukaemia with Burkitt morphology and the 14q+, which did not express lymphoid markers. Instead, the leukaemia was shown to be an acute erythroleukaemia. The erythrocyte marker glycophorin A was present on the surface of the leukemic blasts as shown by immunofluorescence and immunoprecipitation from membrane lysates of surface labeled cells with antiglycophorin A antiserum. Spectrin and fetal hemoglobin appeared after cultivation of the blasts in the presence of sodium butyrate. The present case shows that a short term cultivation is sometimes useful for further characterization of the commitment of acute leukaemias.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Eritroblástica Aguda
/
Mapeamento Cromossômico
/
Cromossomos Humanos 13-15
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article