Long-term immunological investigation of malignant intracranial gliomas.
Surg Neurol
; 16(1): 48-52, 1981 Jul.
Article
em En
| MEDLINE
| ID: mdl-6974407
ABSTRACT
In this study, 118 consecutive adult patients with supratentorial gliomas underwent preoperative immunological monitoring, with particular regard to B-lymphocyte and T-lymphocyte markers. Most patients were treated surgically and with radiotherapy. Three months later, they were readmitted for postoperative immunological investigation and follow-up control. A total of 76 cases could thus be completely investigated and were statistically eligible for evaluation. A pronounced failure of T-cell-mediated immunity was observed "E-active" rosette-forming cells and mitogen-induced blastogenesis tests turned out to be markedly depressed, with a slight postoperative recovery. Spontaneous cell-mediated cytotoxicity was significantly (p less than 0.01) increased both in preoperative and postoperative findings. The main immunodiagnostic patterns (immunoglobulins assay, surface immunoglobulins, "mouse" rosettes) concerning the B-cell-dependent "pool" were found to be within normal limits.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Glioma
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article