Activity of osteoclasts and osteocytes in compact human bone at various ages, both with and without osteoporosis.

ABSTRACT

As part of a programme of research designed to assess the respective roles of osteoclasts and osteocytes in the processes of bone resorption, the metabolic activity of these cells was evaluated indirectly by a morphometric method in the compact bone of human tibias from subjects of various ages, both normal and those affected by osteoporosis. Statistical analysis of the quantitative data was in agreement with the microradiographic examination of the sections, and showed that whereas the intensity of osteoclastic resorption varied in the various subjects according to age, periosteocytic osteolysis--in the classical sense of a phenomenon involving widening of the lacunae detectable with the optical microscope--did not occur in compact bone whether it was normal or highly porotic.