Influences of matrixes on nylon-encapsulated pharmaceuticals.

ABSTRACT

The preparation and properties of nylon microcapsules containing three different matrixes (formalized gelatin, calcium alginate, and calcium sulfate) are described. Microcapsules containing each matrix were dense and free flowing and could be made of very small diameter by controlling the stirring speed during nylon formation. The preparation of microcapsules containing calcium alginate employed freeze-drying procedures. Lyophilization was not necessary with the formalized gelatin and calcium sulfate systems. Various representative drugs (anionic, cationic, nonionic, quaternary, and amphoteric compounds) were used in the formulation studies. The effects of pH, matrix, and encapsulated species on retention of drug in the microcapsules are described. In addition, the surface morphology of the microcapsules was examined using scanning electron microscopy.