Further identification of human plasma glycoproteins interacting with the galactose-specific lectin Jacalin.
J Chromatogr B Biomed Appl
; 668(1): 1-11, 1995 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-7550965
ABSTRACT
In this report we show that Jacalin binds the heme-binding protein hemopexin and the C4b-binding protein sgp120 in human plasma. The interaction of Jacalin with hemopexin confirms that a single O-linked oligosaccharide is sufficient to mediate binding of a protein to this lectin. Retention of sgp120 by immobilized Jacalin demonstrated that this protein was O-glycosylated and, therefore, clearly different from another C4b-binding protein, the complement protein C2 which is physicochemically similar but exclusively N-glycosylated. In addition, Jacalin was also shown to bind several proteolytic enzymes which remain to be identified.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Inativadoras do Complemento
/
Hemopexina
/
Glicoproteínas
/
Proteínas de Transporte
/
Lectinas de Plantas
/
Galactose
/
Lectinas
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article