Effects of KW-3902, an adenosine A1-receptor antagonist, on ascites volume in puromycin aminonucleoside (PAN)-induced nephrotic rats.
Jpn J Pharmacol
; 68(2): 213-6, 1995 Jun.
Article
em En
| MEDLINE
| ID: mdl-7563979
ABSTRACT
We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine A1-receptor antagonist can be an effective diuretic to ameliorate edema.
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Base de dados:
MEDLINE
Assunto principal:
Ascite
/
Xantinas
/
Puromicina Aminonucleosídeo
/
Diuréticos
/
Antagonistas de Receptores Purinérgicos P1
/
Nefrose
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article