[State of lipid peroxidation and blood antioxidant system in patients with occlusive arterial diseases of the limbs]. / Stan perekysnoho okyslennia lipidiv i antyoksydantnoï systemy krovi u patsiientiv z okliuzuiuchymy zakhvoriuvanniamy arterii kintsivok.

ABSTRACT

In 95 patients with atherosclerotic occlusion of aorto-iliac and femoro-popliteal arterial segments and II-IV grade of ischemia (according to Fontaine) the concentration of malonic dialdehyde and general antioxidant activity of the blood plasma in ischemia period of time and in various terms of revascularization period were determined. The processes rising of peroxide clearance of lipids (PCL) in injured limb and lowering of antioxidant (AO) activity of blood plasma was discovered. In the revascularization period further significant activation of PCL processes (maximally during the first day) and gradual rising of AO activity of blood plasma (maximally on the 3-5th day) was revealed. The magnitude of these processes depended on the tissue ischemia extension and its severity.